Microfiber-based Sensor for Measuring Uric Acid Concentrations

N. Saidin, N.F. Idris, M.N. Amaluddin, N. Irawati, A.A.M. Ralib, S.W. Harun


Microfiber sensor is proposed and demonstrated using a fiber optic displacement sensor (FODS) based on intensity modulation technique for measurement of different concentrations of uric acid. The proposed sensor uses singlemode fiber (SMF) tapered using flame brushing technique to enhance the evanescent field around the fiber core to interact with the uric acid. The tapered area is bent manually and sets vertically on a clamp, facing the mirror in the beaker. It is placed within the linear range of a sensor’s displacement curve of 0 to 5000 µm. The calibration of tapered fiber sensor was done both in the air and diluted water. The sensor is capable of measuring the concentrations of uric acid from 100 ppm to 500 ppm with a measured sensitivity of 0.0218 dBm/ppm. The linearity and resolution of the proposed sensor are 99.21% and 28.219 ppm, respectively. In addition, the proposed microfiber FODS sensor using SMF exhibit good stability and repeatability. It provides numerous advantages in terms of simple design, less production cost and operation without forfeiting its sensitivity.


Displacement sensor; Microfiber; Single-mode fiber; Uric acid concentration;

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Minas, G., Martins, J. S., Ribeiro, J. C., Wolffenbuttel, R. F., & Correia, J. H. (2004). Biological microsystem for measuring uric acid in biological fluids. Sensors and Actuators A: Physical, 110(1), 33-38.

Johnson, R. J., Kang, D. H., Feig, D., Kivlighn, S., Kanellis, J., Watanabe, S., ... & Mazzali, M. (2003). Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?. Hypertension, 41(6), 1183-1190.

Hoshi, T., Saiki, H., & Anzai, J. I. (2003). Amperometric uric acid sensors based on polyelectrolyte multilayer films. Talanta, 61(3), 363- 368.

Zhao, C., Wan, L., Wang, Q., Liu, S., & Jiao, K. (2009). Highly sensitive and selective uric acid biosensor based on direct electron transfer of hemoglobin-encapsulated chitosan-modified glassy carbon electrode. Analytical Sciences,25(8), 1013-1017.

Ali, S. M. U., Ibupoto, Z. H., Kashif, M., Hashim, U., & Willander, M. (2012). A potentiometric indirect uric acid sensor based on ZnO nanoflakes and immobilized uricase. Sensors, 12(3), 2787-2797.

Liao, C. W., Chou, J. C., Sun, T. P., Hsiung, S. K., & Hsieh, J. H. (2006). Preliminary investigations on a new disposable potentiometric biosensor for uric acid. Biomedical Engineering, IEEE Transactions on, 53(7), 1401-1408.

M. Batumalay, Z. Harith, H.A. Rafaie, F. Ahmad, M. Khasanah, S.W. Harun, R.M. Nor, H. Ahmad, Tapered plastic optical fiber coated with ZnO nanostructures for the measurement of uric acid concentrations and changes in relative humidity, Sensors and Actuators A: Physical, Volume 210, 2014, Pages 190-196, ISSN 0924-4247.

Malathy Batumalay, F. Ahmad, Asiah Lokman, A.A. Jasim, Sulaiman Wadi Harun, H. Ahmad, (2014) "Tapered plastic optical fiber coated with single wall carbon nanotubes polyethylene oxide composite for measurement of uric acid concentration", Sensor Review, Vol. 34 Issue: 1, pp.75-79

M. Batumalay, S. W. Harun, F. Ahmad, R. M. Nor, N. R. Zulkepely and H. Ahmad, "Tapered Plastic Optical Fiber Coated With Graphene for Uric Acid Detection," in IEEE Sensors Journal, vol. 14, no. 5, pp. 1704-1709, May 2014.

Polygerinos, P., Seneviratne, L. D., & Althoefer, K. (2011). Modeling of light intensity-modulated fiber-optic displacement sensors. IEEE Transactions on Instrumentation and Measurement, 60(4), 1408-1415.

S. W. Harun, M. Yasin, H. Z. Yang and H. Ahmad, Fiber Optic Displacement Sensors and Their Applications, Fiber Optic Sensors, Dr Moh. Yasin (Ed.), InTech,(2012).


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