Reversing Paralysis Technology - Remarkable Breakthrough for the Treatment of Incurable Paralysis
Abstract
This research has been developed
to study on the Brain Computer Interface (BCI)
technology - which is called a Reversing Paralysiss
Technology. It is a momentous innovation of
medical sector for the treatment of Incurable
Paralysis. The purpose of this study was to provide
a high level of evidences of the effectiveness and
the safety of this technology. The methodology of
this study is using a qualitative systematic review
method. It was followed by data collection and
specific keywords based data searching method.
Two renowned research papers indexing database
have been employed for locating peer reviewed
scientific papers such as Pub-Med Database and
Google Scholar Database. Besides this database
searching, the Google Search also performed for
collecting scientific review news and informations
regarding this technology. Researchers analysed
all keyword based from the selected literatures,
from the clinical trial results and from the new
sources; and then summarizes the findings in
respect of this technology. In this technology,
the scientists have hypothesized that reversing
of the paralyzed state of a patient is possible by
creating Brain Computer Interfaces (BCIs) in the
patient’s body through two brain implants. One
implant is placed on the surface of the brain or
attached to the brain's cortex. Then, another one
is implanted in the spinal cord by passing the
injured lesion of spine. These two implants will
act as a bridge between the command center (the
brain) and the control center (the spine). When the
regular communication is established between
the brain and the spine, then the paralyzed
condition will reverse. The researchers, till to this
date have analysed thirty seven (37) peer reviewed
literatures, twelve (12) scientific/tech based news
review sources and four (4) authentic clinical trial
results which had been published in this context.
Scientists claimed that this theory is effective and
is safe for the treatment of paralysis based on
successful clinical trials. Thus, from this extensive
qualitative systematic review study, it established
a theory that Reversing Paralysis Technology is
working through Brain Computer Interfaces -
Implants mechanism; and it is an effective and a
safe process for patients’ paralysis treatment.
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Lloyd Price of Healthcare Digital, “Neural
Implants And The Race To Merge The Human
Brain With Artificial Intelligence,” October, 2017.
World Health Organization, “Neurological
Disorders - public health challenges,” ISBN 92 4
2. (NLM classification: WL 140). ISBN 978
4 156336 9, 2006.
European Brain Council (EBC), “Value of
Treatment for Brain Disorders, Discussion
Paper,” February, 2018
F. Bukachi and N.Pakenham-Walsh, “Information
Technology for Health in Developing Countries,”
Chest Journal, 132; 1624-1630), DOI 10.1378/
chest.07-1760, 2007.
LTH Tan and KL Ong, “The impact of medical
technology on healthcare today,” Hong Kong j.
emerg. med. Vol. 9(4) Oct 2002.
M. Capogrosso, T. Milekovic, D. Borton, F.
Wagner, E.M. Moraud, J.B. Mignardot, N. Buse,
J. Gandar, Q.Barraud, D. Xing, and E. Rey, “A
brain–spine interface alleviating gait deficits after
spinal cord injury in primates,” Nature Journal,
(7628), p.284, 2016.
C. Ethier, E.R. Oby, M.J. Bauman, and L.E. Miller,
“Restoration of grasp following paralysis through
brain-controlled stimulation of muscles,” Nature
Journal, 485(7398), p.368, 2012.
J.L. Collinger, B. Wodlinger, J.E. Downey,
W. Wang, E.C. Tyler-Kabara, D.J. Weber, A.J.
McMorland, M. Velliste, M.L. Boninger, and A.B.
Schwartz, “High-performance neuroprosthetic
control by an individual with tetraplegia,” The
Lancet, 381(9866), pp.557-564, 2013.
MIT Technology Review, 10 Breakthrough
Technologies 2017.
L.R. Hochberg, D. Bacher, B. Jarosiewicz, N.Y.
Masse, J.D. Simeral, J. Vogel, S. Haddadin, J. Liu,
S.S. Cash, P. van der Smagt, and J.P. Donoghue,
“Reach and grasp by people with tetraplegia
using a neurally controlled robotic arm,” Nature
Journal, 485(7398), p.372, 2012.
S. Blumenthal, “How Science Is Crucial To
Improving Health Worldwide”, Huffingtonpost
Blog, May 25, 2011.
E. Strickland, “One Small Step for a Paraplegic,
One Big Step Toward Reversing Paralysis”, IEEE
Spectrum: Technology, Engineering, and Science
News, May 2017.
Government Office for Science. UK, Technology
and innovation futures 2017.
W. Jeremy, "Air pollution and brain health: an
emerging issue." Lancet 390: 1345-422, 2017.
World Health Organization, WHO global
disability action plan 2014-2021, 2017
The Deloitte Centre for Health Solutions,
Connected Health. How digital technology is
transforming health and social care, 2015.
R. Vargas, and J. Ponce-Canchihuamán,
“Emerging various environmental threats to
brain and overview of surveillance system with
zebrafish model. Toxicology reports, 4, pp.467-
, 2017.
M.H. Forouzanfar, A. Afshin, L.T. Alexander,
H.R. Anderson, Z.A. Bhutta, S. G. Biryukov,
“Regional, and national comparative risk
assessment of 79 behavioural, environmental
and occupational, and metabolic risks or clusters
of risks, 1990–2015: a systematic analysis for
the global burden of disease Study,” Lancet,
(10053):1659–1724, 2016.
M. Okur, H. Geylani, H. Caksen, O. Tuncer, B.
Atas, C. Yilmaz, “Chronic mercury poisoning:
report of two siblings,” Indian J. Occup. Environ,
Med, 14(1):17, 2010.
J.J. Daly, and J.R. Wolpaw, “Brain–computer
interfaces in neurological rehabilitation. The
Lancet Neurology,” 7(11), pp.1032-1043, 2008.
J.L. Contreras-Vidal, A. Presacco, H. Agashe, and
A. Paek, “Restoration of whole body movement:
toward a noninvasive brain-machine interface
system. IEEE pulse,” 3(1), pp.34-37, 2012.
A. Burns, H. Adeli, and J.A. Buford, “Brain–
computer interface after nervous system injury,”
The Neuroscientist, 20(6), pp.639-651, 2014.
H.S. Anupama, N.K. Cauvery, and G.M.
Lingaraju, “Brain computer interface and its
types-a study. International Journal of Advances
in Engineering & Technology,”3(2), p.739, 2012.
S.N. Abdulkader, A. Atia, and M.S.M. Mostafa,
“Brain computer interfacing: Applications and
challenges. Egyptian Informatics Journal,” 16(2),
pp.213-230, 2015.
N. Birbaumer, A.R. Murguialday, and L. Cohen,
“Brain–computer interface in paralysis,” Current
opinion in neurology, 21(6), pp.634-638, 2008.
D.C. Mariano, C. Leite, L.H. Santos, R.E. Rocha,
and R.C. de Melo-Minardi, “A guide to performing
systematic literature reviews in bioinformatics,”
arXiv preprint arXiv: 1707.05813, 2017.
W. Ham-Baloyi, and P. Jordan, “Systematic
review as a research method in post-graduate
nursing education,” health sa gesondheid, 21,
pp.120-128, 2016.
F. Dochy, “A guide for writing scholarly articles
or reviews for the Educational Research Review,”
Educational Research Review, 4, pp.1-2, 2006.
BrainandSpinalCord.org, “Is there a cure for
paralysis, and will my loved one ever walk
again?”
K Nas, L Yazmalar, V Şah, A Aydın,
“Rehabilitation of spinal cord injuries”, World
journal of orthopedics, 6 (1), p.8, 2015.
T. Acharya, “Science and technology for wealth
and health in developing countries,” Global Public
Health, 2(1), pp.53-63, 2007.
G. Sharma, N. Annetta, D.A. Friedenberg, and M.
Bockbrader, “Advances in BCI: A Neural Bypass
Technology to Reconnect the Brain to the Body,”
In Brain-Computer Interface Research, Springer,
Cham, (pp. 9-20), 2017.
C. Willyard, “How It Works: A System That
Reverses Paralysis,” Popular Science, July, 2014.
H.S. Chhabra, S. Batra, “Spinal Cord Injury
and its Impact on the Patient, Family, and the
Society,” Int J Recent Surg Med Sci, 2(1):1-4, 2016.
E. U. Medina, and R.M. Barría Pailaquilén,
“Systematic review and its relationship with
evidence-based practice in health,” Revista latinoamericana
de enfermagem, 18(4), pp.824-831, 2010.
A. Siddaway, “What is a systematic literature
review and how do I do one,” University of
Stirling, (I), p.1, 2014.
E. Aromataris, and D. Riitano, “Constructing a
search strategy and searching for evidence,” AJN the
American Journal of Nursing, 114(5), pp.49-56, 2014.
A. Silverman, “Paraplegic man stands, steps
with assistance and moves his legs voluntarily,”
UCLA News. May 19, 2011.
S. Harkema, Y. Gerasimenko, J. Hodes, J. Burdick,
C. Angeli, Y. Chen, C. Ferreira, A. Willhite, E. Rejc,
R.G. Grossman, and V.R. Edgerton, “Effect of
epidural stimulation of the lumbosacral spinal cord
on voluntary movement, standing, and assisted
stepping after motor complete paraplegia: a case
study,” The Lancet, 377(9781), pp.1938-1947, 2011.
E. Rejc, C.A. Angeli, D. Atkinson, and S.J.
Harkema, “Motor recovery after activity-based
training with spinal cord epidural stimulation in
a chronic motor complete paraplegic,” Scientific
reports, 7(1), p.13476, 2017.
R. Laming and S.Wolpert, “Breakthrough therapy
allows four paraplegic men to voluntarily move
their legs,” UCLA News,| April 08, 2014.
M. Capogrosso, T. Milekovic, D. Borton, F.
Wagner, E.M. Moraud, J.B. Mignardot, N. Buse,
J. Gandar, Q.Barraud, D. Xing, and E. Rey, “A
brain–spine interface alleviating gait deficits after
spinal cord injury in primates,” Nature Journal,
(7628), p.284, 2016.
V. K. Mushahwar, L. Guevremont, and R. Saigal,
“Could cortical signals control intraspinal
stimulators? A theoretical evaluation,” IEEE Trans.
Neural Syst. Rehabil, Eng. 14, 198–201, 2006.
A. R. Donati, S. Shokur, E. Morya, D. S. Campos,
R. C. Moioli, C. M. Gitti, and F. L. Brasil, “Longterm
training with a brain-machine interfacebased
gait protocol induces partial neurological
recovery in paraplegic patients,” Scientific reports,
, 30383, 2016.
N. Alexeeva, C. Sames, P.L. Jacobs, L. Hobday,
M.M. DiStasio, S.A. Mitchell, and B. Calancie,
“Comparison of training methods to improve
walking in persons with chronic spinal cord
injury: a randomized clinical trial,” The journal of
spinal cord medicine, 34(4), pp.362-379, 2011.
G.M. Friehs, V.A. Zerris, C.L. Ojakangas, M.R.
Fellows, and J.P. Donoghue, “Brain–machine and
brain–computer interfaces,” Stroke, 35(11 suppl
, pp.2702-2705, 2004.
Actualinfo.website, “Scientists have restored
motor function of paralyzed monkeys,” Nov 11,
E. Klein, and C. S. Nam, “Neuroethics and braincomputer
interfaces (BCIs),” 2016.
W. Glannon, “Ethical issues in neuroprosthetics,”
J. Neural Eng, 13(2):021002. doi:10.1088/1741-
/13/2/021002, 2016.
E.P. Klein, “Redefining the clinical relationship
in the era of incentives,” Am J Bioeth, 12:26–27,
R.L. Wilson, “Ethical Issues of Brain Computer
Interfaces (BCI),” online article, 2013.
J. Howard, “Paraplegics moving again years after
injuries,” CNN, August 11, 2016
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